Kids. Promethazine/codeine shouldn't be Employed in any kid youthful than 12 yrs of age or in a kid youthful than eighteen years of age after a medical procedures to eliminate their tonsils or adenoids (tonsillectomy and/or adenoidectomy). Sluggish or shallow respiratory that can result in death may possibly manifest.
Use an accurate measuring machine to measure your dose of promethazine/codeine. A household spoon is not really an exact measuring gadget and will induce you to consider the wrong dose. Check with your pharmacist to suggest an ideal measuring product.
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, demanding careful consideration of the effects around the mum or dad drug, codeine, along with the Lively metabolite, morphine.
The narcotic antagonist, naloxone hydrochloride, could possibly be administered when considerable respiratory despair takes place with promethazine and codeine; any depressant consequences of promethazine will not be reversed with naloxone. Diazepam may very well be utilised to control convulsions. Stay away from analeptics, which may induce convulsions. Acidosis and electrolyte losses need to be corrected. A rise in temperature or pulmonary complications may well signal the necessity for institution of antibiotic therapy.
Presents quickly and helpful ache aid, offering as many as eight hrs of pain aid ( dependant on a 400mg dose)
When you have been taking promethazine/codeine consistently, will not end using the medication without speaking with your healthcare company. Halting as well quickly could result in significant side effects. Connect with get more info your healthcare company without delay For those who have any of the subsequent symptoms.
Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even when, for its worthwhile psychological or physiological outcomes.
The next adverse reactions are actually recognized during medical research, within the literature, or during put up-acceptance use of codeine and/or promethazine.
Promethazine/codeine can have an impact on your alertness or coordination. Don't travel or do other things to do that get more info need alertness or coordination right up until you understand how promethazine/codeine influences you.
Sedating prescription drugs may perhaps cause confusion and in excess of-sedation in the elderly; elderly clients frequently must be began on low doses of Promethazine Hydrochloride and Codeine Phosphate Syrup and noticed carefully.
No codeine more info linctus dose is usually recommended for youngsters because this drug has the risk of respiratory problems and various difficulties.
Serious get more info hypotension commonly responds to the administration of norepinephrine check here or phenylephrine. EPINEPHRINE Shouldn't be Made use of, given that its use in a very affected person with partial adrenergic blockade may even more lessen the blood pressure.
Codeine Codeine is an opioid agonist comparatively selective for that mu-opioid receptor, but with a A lot weaker affinity than morphine. The analgesic and antitussive Homes of codeine are speculated to originate from its conversion to morphine.
No proof of tumorigenicity was observed in male and feminine mice at codeine dietary doses nearly 400 mg/kg/day (somewhere around equivalent to 45 instances the MRHD over a mg/m2 basis).